Wanderers make 10 changes to their starting line-up for their first-round Carabao Cup tie.
Jordi Osei-Tutu is the only player from Saturday’s winning team against Plymouth who starts again for the visit of Championship outfit Wednesday.
Whites’ boss Steven Schumacher hands a debut to new signing Tyler Miller in goal, while there are also first starts in a Wanderers’ shirt for summer recruits Ethan Erhahon and Charlie Warren.
Teenager Daeshon Lawrence makes a full debut in attack for the Whites, with striker Mason Burstow named among the substitutes after scoring on his first home start last weekend.
Wednesday also have one player named again from their last league line-up, with goalkeeper Pierce Charles starting on the back of Sunday's 2-1 Championship loss at Leicester City.
The Owls hand out five debuts and include eight Academy players in their line-up on the back of a summer of discontent which has left their senior squad stretched.
The winners of tonight’s tie, which will be decided on penalties if the scores are level after 90 minutes, will be at home to Premier League side Leeds United in round two.
Wanderers: Miller, Dacres-Cogley, Forino, Mendes Gomes, Osei-Tutu, Morley, Erhahon, Inwood, Warren, Lawrence, McAtee. Substitutes: Broome, Simons, Johnston, Sheehan, Gale, Randall, Cozier-Duberry, Conway, Burstow.
Sheffield Wednesday: Charles, Ugbo, McNeill, Kobacki, Shipston, Siqueira, Johnson, Waever, Emery, Fernandes, Thornton. Substitutes: Stretch, Palmer, Lowe, Fusire, Lowe, Grainger, Alao, Kamwa.
Referee: Oliver Langford